Evidence of Shared Genome‐Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users
Year: 2016
Type: article
Abstract: Exposure to traumatic experiences is associated with an increased risk for drug dependence and poorer response to substance abuse treatment (Claus & Kindleberger, 2002; Jaycox, Ebener, Damesek, & Becker, 2004). Despite this evidence, the reasons for the observed associations of trauma and the general tendency to be dependent upon drugs of abuse remain unclear. Data (N = 2,596) from the Study of Addiction: Genetics and Environment were used to analyze (a) the degree to which commonly occurring single nucleotide polymorphisms (SNPs; minor allele frequency > 1%) in the human genome explains exposure to interpersonal traumatic experiences, and (b) the extent to which additive genetic effects on trauma are shared with additive genetic effects on drug dependence. Our results suggested moderate additive genetic influences on interpersonal trauma, h(2) SNP-Interpersonal = .47, 95% confidence interval (CI) [.10, .85], that are partially shared with additive genetic effects on generalized vulnerability to drug dependence, h(2) SNP-DD = .36, 95% CI [.11, .61]; rG-SNP = .49, 95% CI [.02, .96]. Although the design/technique does not exclude the possibility that substance abuse causally increases risk for traumatic experiences (or vice versa), these findings raise the possibility that commonly occurring SNPs influence both the general tendency towards drug dependence and interpersonal trauma.
Source: Journal of Traumatic Stress
DOI: 10.1002/jts.22103
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: Biomarkers, social, and affective predictors of suicidal thoughts and behaviors in adolescents, Psychogenetic Factors in Project REACH, Study of Addiction: Genetics and Environment, Estimating the genetic and environmental architecture of psychiatric disorders, Prenatal tobacco exposure: effects on neuropsychological outcomes and ADHD, The Collaborative Genetic Study of Nicotine Dependence, Genome Wide Association Coordinating Center, Systems Genetics of Alcoholism: Network-based Approaches for Genetics Association, JH/CIDR Genotyping for Genome-Wide Association Studies, FAMILY STUDY OF COCAINE DEPENDENCE, Mechanisms of Intergenerational Impact of Maternal Trauma, Deconstructing the Smoking and ADHD Comorbidity: A Multilevel Genetic Approach, Collaborative Study on the Genetics of Alcoholism (COGA).
OpenAlex ID: W2405133123