Valoración de la citología y la colposcopia como pruebas de detección precoz del cáncer de cuello uterino en pacientes del Instituto Nacional Materno Perinatal
Year: 2016
Type: dissertation
Study design: Observational Study
Abstract: --- OBJECTIVES: To assess the validity of Pap smear and colposcopy as screening tests for moderate dysplasia, severe dysplasia, carcinoma in situ or cervical cancer. METHODS: A cross-sectional retrospective study was performed. The population consisted of patients who required treatment under LEEP conization in the period 2012-2015. A review of medical records was conducted to obtain a sample by following the criteria of inclusion and exclusion. The estimation of sensitivity, specificity, positive and negative predictive value of the tests were performed in order to assess the validity of both tests. For this purpose it was taken as a cutpoint to moderate dysplasia (CIN II) or a greater injury to consider a positive result. To compare both tests, a comparison of the area under the ROC curve (AUC) of such tests was developed. RESULTS: Sensibility, specificity, positive predictive value and negative predictive value of Pap smear were 39.66%, 91.38%, 82.14%, 60.23% respectively. Sensibility, specificity, positive predictive value and negative predictive value of colposcopy were 77.59%, 63.79%, 68.18%, 74% respectively. The area under ROC curve of colposcopy was 0.7201 was greater than the area under ROC curve of cytology which had a value of 0.6892, suggesting a better ability of discrimination of the disease. CONCLUSIONS: Pap smear and colposcopy are clinically useful tests for detecting moderate dysplasia, severe dysplasia, carcinoma in situ and invasive carcinoma. Cytology has a low sensitivity for the high rate of false negatives possibly because of a low quality in the test procedure. Keywords: Pap smear, colposcopy , high-grade intraepithelial lesions , diagnostic validity.
Authors: Valerio Ventocilla, Ingrid Gabriela
Language: Spanish
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2405464025