Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models
Year: 2016
Type: article
Abstract: Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
Source: Scientific Reports
DOI: 10.1038/srep19399
Institutions: Centre National de la Recherche Scientifique, Université Clermont Auvergne, AgroParisTech, Microbiologie de l’alimentation au service de la santé, Laboratoire Microorganismes Génome et Environnement, Université de Clermont I, Inserm, Physiopathologie et pharmacologie de la douleur et de la migraine, Université Toulouse III - Paul Sabatier, Institut National Polytechnique de Toulouse, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Toxicologie Alimentaire, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Laboratoire des Biomolécules, Université Pierre-et-Marie-Curie
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2405482068