Bisphenol a influences blastocyst implantation via regulating integrin β3 and trophinin expression levels.
Year: 2015
Type: article
Abstract: OBJECTIVE: This study is to investigate effects of bisphenol A (BPA) on the blastocyst implantation in endometrium. METHODS: Pregnant mice were orally administered with BPA. Implantation sites were examined, and serum estrogen level was assayed with ELISA. Protein expression levels were detected with immunohistochemistry and immunofluorescence staining. RESULTS: High doses (400 and 600 mg/kg/day) of BPA remarkably reduced the implantation sites in the pregnant mice. No significant differences were observed in the serum estrogen level across the groups. Moreover, high doses (400 and 600 mg/kg/day) of BPA significantly declined the expression level of endometrial estrogen receptor α (ERα) in the pregnant mice. In addition, high doses (400 and 600 mg/kg/day) of BPA significantly declined the expression levels of integrin β3 and trophinin in the endometrium and blastocysts. CONCLUSION: BPA declines ERα expression in endometrium, and inhibits adhesion protein expression in endometrium and blastocysts, causing the adhesion failure of blastocyst implantation.
Source: PubMed Central
Authors: Xiaoyan Pan, Xiyan Wang, Zhengchao Wang, Xuenan Wang, Zhaohua Dou, Zhixin Li
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2405576856