Clinical Development of TargomiRs, a miRNA Mimic-Based Treatment for Patients with Recurrent Thoracic Cancer
Year: 2016
Type: review
Abstract: miRNAs are responsible for post-transcriptional control of gene expression, and are frequently downregulated in cancer. It has become well established that restoring miRNA levels can inhibit tumor growth, and many studies have demonstrated this in preclinical models. This in turn has led to the first clinical trials of miRNA replacement therapy. This special report focuses on the development of TargomiRs - miRNA mimics delivered by targeted bacterial minicells - and the very first clinical experience of a miRNA replacement therapy in thoracic cancer patients in the Phase I MesomiR-1 trial.
Source: Epigenomics
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Funder: Cancer Institute NSW
Awards: G4756564038, G5012965504
OpenAlex ID: W2405641869