Work

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes

Year: 1998

Type: article

Abstract: Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

Source: Biochemical Journal

DOI: 10.1042/bj3300599

Authors: David THOMAS, Hak Yong KIM, Roseline MORGAN, R. Michael HANLEY

Institution: University of California, Davis

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: TRAINING IN CARDIOVASCULAR AND NEUROPHYSIOLOGY, G971558908