Work

Stress and the cell nucleus: dynamics of gene expression and structural reorganization.

Year: 1999

Type: article

Abstract: A growing number of experimental observations reveal that the cell nucleus is functionally compartmentalized yet organized to ensure a dynamic response to events that influence nuclear activities. The cellular and molecular response to physiological and environmental stress induces a rapid and transient change in gene expression associated with major changes in nuclear architecture that impacts on signals involved in cell growth. In this review, we will address the effects of stress on the functional compartmentation of the cell nucleus and the dynamic reorganization of nuclear structures and function.

Source: Europe PMC (PubMed Central)

Authors: C Jolly, R I Morimoto

Institution: Northwestern University

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: A Systems Approach to Stress Biology and Proteostasis Networks, REGULATION AND EXPRESSION OF THE HSP70 GENE FAMILY

OpenAlex ID: W2406411892

FWCI: 0.671

Cites: 86

Cited by: 48

Related to: 10