Work

Changes in Expression of Apoptosis-associated Molecules in Hypothalamic Neurosecretory Cells of Miceduring Aging

Year: 2006

Type: article

Abstract: The aim of work was to study the peculiarities of apoptosis regulation in neurosecretory centers of old (aged 18 months) mice treated with immunomodulator interferon alpha (IFN-alpha) as compared to young (aged 2 months) mice. It was shown that age-related apoptosis activation in supraoptic (SON) and paraventricular (PVN) nuclei was mediated by different molecular mechanisms and could result from the alterations of the balance of apoptosis-associated proteins, including the synthesis of proapoptotic (Bax) and antiapoptotic (Mcl-1, Bcl-2) molecules. Besides, the apoptosis signal cascade in young mice treated with IFN-alpha was identical in both nuclei, whereas in old mice there were some differences between SON and PVN.

Source: Morphology

DOI: 10.17816/morph.402446

Authors: E D Bazhanova, V N Molodtsov, K I Pavlov, Ye D Bazhanova, V N Molodtzov, K I Pavlov

Institutions: Institute of Evolutionary Physiology and Biochemistry, University of Medicine and Dentistry of New Jersey, Herzen University

Language: Russian

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4394589589

FWCI: 0.113

Cites: 16

Cited by: 2

Related to: 10