Work

An overview of mammalian pluripotency

Year: 2016

Type: article

Abstract: Mammalian pluripotency is the ability to give rise to all somatic cells as well as the germ cells of an adult mammal. It is a unique feature of embryonic epiblast cells, existing only transiently, as cells pass through early developmental stages. By contrast, pluripotency can be captured and stabilized indefinitely in cell culture and can also be reactivated in differentiated cells via nuclear reprogramming. Pluripotent stem cells (PSCs) are the in vitro carriers of pluripotency and they can inhabit discrete pluripotent states depending on the stage at which they were derived and their culture conditions. Here, and in the accompanying poster, we provide a summary of mammalian pluripotency both in vivo and in vitro, and highlight recent and future applications of PSCs for basic and translational research.

Source: Development

DOI: 10.1242/dev.132928

Authors: Jun Wu, Takayoshi Yamauchi, Juan Carlos Izpisua Belmonte

Institution: Salk Institute for Biological Studies

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Leona M. and Harry B. Helmsley Charitable Trust, Consorzio Interuniversitario Biotecnologie, Moxie Foundation