Work

IgG4-Related Kidney Disease in a Patient With History of Breast Cancer

Year: 2016

Type: article

Abstract: A 64-year-old African American woman with history of stage III breast carcinoma, 3 years after complete response to therapy, presents with progressive fatigue, increasing arthralgia, and unintentional weight loss of 15 lb in 3 months. An F-FDG PET demonstrated new diffuse FDG avidity of the renal parenchyma, new FDG-avid foci in pancreas and lungs, and new FDG-avid lymph nodes above and below the diaphragm. While a retroperitoneal lymph node biopsy was inconclusive, a kidney biopsy resulted in diagnosis of diffuse, severe, IgG4-related tubulointerstitial nephritis. Treatment with corticosteroid led to complete resolution of the symptoms and PET findings.

Source: Clinical Nuclear Medicine

DOI: 10.1097/rlu.0000000000001252

Authors: Simone Krebs, Serena Monti, Surya Seshan, Josef Fox, Lorenzo Mannelli

Institutions: Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, SDN Istituto di Ricerca Diagnostica e Nucleare

Language: English