Diversity and Tropism of HIV-1 Rebound Virus Populations in Plasma Level After Treatment Discontinuation
Year: 2016
Type: article
Abstract: Human immunodeficiency virus-infected people discontinuing therapy experience a rebound in the virus level (hereafter, "rebound virus") from a persistent reservoir. We examined 10 samples from patients in AIDS Clinical Trials Group study A5068 with rebound virus, using single-genome amplification and Primer ID deep sequencing, to assess env genetic diversity of the virus population. Most rebound-virus populations showed significant diversity. All env examined required high levels of CD4 for entry, consistent with selection of replication in CD4(+) T cells. These results indicate that most people discontinuing therapy release a diverse population of virus and that this released virus has entry features of virus selected for replication in CD4(+) T cells, rather than in myeloid cells.
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1819583291, G2127051194, G285461174, G3810609436, G4553935269, G6030256224, G857487509, G9000039438, G9000047228, G9000182931, G9000292181, AIDS Clinical Trial Group Laboratory Center, The University of North Carolina Center for AIDS Research, University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit
OpenAlex ID: W2407822646