[GABA receptors: structure and functions].
Year: 2010
Type: article
Abstract: Data on the structure, localization, physiology and pharmacology of GABA(C) receptors are reviewed. Thece receptors belong to cys-loop receptors and consist of rho1-3 subunits representing pentamers with five subunits that form a chloride channel. They are found in both central nervous system and peripheral organs. The pentamer can be homomeric, consisting of five similar protomers (e.g., p1), or heteromeric (pseudo-homomeric), consisting of rho1 and rho2 subunits. Chloride channel function also depends on the GABA(C) receptor subunit composition. The activation of GABAc receptors is accompanied by a change in the permeability of plasmatic membranes for C1 ions, which is followed by depolarization (presynaptic inhibition) or hyperpolarization (postsynaptic inhibition). There are a great number of the allosteric modulators, agonists and antagonists of GABA(C) receptors.
Source: PubMed
Authors: I N Tiurenkov, V N Perfilova
Institution: Volgograd State Medical University
Language: Russian
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W1553838284