Prevalence of Human Leukocyte Antigen (HLA DQ2 and DQ8) in Celiac Disease in Patients with Irritable Bowel Syndrome
Year: 2015
Type: article
Study design: Observational Study
Abstract: Background &objectives: Celiac disease is a gastrointestinal disorder that genetic factors have a role on its pathogenesis. The aim of the present study was to determine HLA alleles encoding HLA DQ2 and HLA DQ8 in patients with celiac disease. Methods: This descriptive analytical study was conducted on 105 patients with IBS whom referred to the gastroenterology unit in Ardabil, Iran. The patients with positive celiac serology of IgA anti-tTG test were done an endoscopic duodenal biopsy. HLA DQ2 and DQ8 testings were performed on patients. Data were analyzed using descriptive statistics together with Mann-Whitney U and Fishers exact tests by SPSS-16. Results: 14 patients were found positive for IgA antibodies against tTG. From these 14 patients 2(14.3%) were male and 12 (85.71%) female. All of 14 patients (100% of case) had also abnormal intestinal pathology according to the modified Marsh classification and 10 patients had type IIIC. 11 patients had only HLA DQ2, 2 patients had only HLADQ8, and one patient had both HLADQ2 andDQ8. Conclusion: Most of patients had positive HLA D Q2. The present study emphasizes that HLA genotypes are an important background to CD development.
Authors: A Houshiyar, N Fouladi, F Ghorbani, R Mohammadi, H AlimohammadiAsl
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2408464418