Year: 2009
Type: article
Abstract: IntroductionThe legacy of transplantation in the modern age Cost vs. Benefit: Barriers to positive outcomes in transplantation Enemy at the Gates: Transplantation and the alloimmune response GPS Navigation: Chemokine axes in allograft rejection Putting on the Brakes: Regulating the response to alloantigen Do the regulators need direction too?Frontiers in Immunosuppression: Chemokine antagonism Is there more to the story?Chemokines in priming Chapter 2: Methods Chapter 3: CCR5 is Required for Regulation of Alloreactive T cell Responses to Single Class II MHC-mismatched Murine Cardiac Grafts Wild-type and CCR5 -/-Tregs have equivalent suppressive capacity in vitro 48 Transfer of wild-type CD4 + CD25 + T cells restores bm12 graft survival in CCR5 -/-recipients 50 Re-transplant of bm12 grafts from wild-type to CCR5-deficient recipients does not confer Prolonged survival 52 Discussion 56 Chapter 4: CXCR3 Antagonism Impairs the Development of Donor-Reactive, IFN-γ-producing Effectors and Prolongs Allograft Survival Ex vivo-primed effector cells infiltrate allografts despite blockade of CXCR3 with AMG1237845 CXCR3 antagonism does not alter the proliferative capacity of donor-reactive CD8 + T cells Generation of IFN-γ-producing CD8 T cells is depressed by CXCR3 antagonism Sub-therapeutic costimulatory blockade synergizes with CXCR3 antagonism to prolong allograft survival
Author: Joshua Rosenblum
Institution: Case Western Reserve University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2408486649