The effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro.
Year: 1979
Type: article
Abstract: Human blood B-lymphocytes were co-cultured with in vitro irradiated allogeneic or autologous T-lymphocytes in the presence of pokeweed mitogen (PWM). The production of IgG, IgM and IgA, as assessed by the enzyme-linked immunosorbent assay (ELISA) was increased 2--7 times, as compared to values obtained with non-irradiated T-lymphocytes. It is suggested that the increase of Ig production is due to the selective radiosensitivity of T-lymphocytes with suppressor function.
Source: PubMed Central
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2409035429