PPAR gamma agonist reduces amyloid pathology in aged senescence mice model : mechanisms involving LRP1 expression
Year: 2014
Type: dissertation
Abstract: Objective.The role of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in Alzheimer's disease (AD) is still controversial.Low-density lipoprotein receptor-related protein 1 (LRP1) is known to play an important role in secretion of amyloid-β (Aβ) in AD.The current study is carried out to investigate the effect of pioglitazone, PPAR-γ agonist, on Aβ deposition, LRP1 expression, and memory impairment in a senescence mouse model. Methods.Pioglitazone was orally administrated to 9-month-old SAMP8 mice in variable doses (0.5 mg/kg/day, 2 mg/kg/day and 5 mg/kg/day) for 7 weeks.Memory function was assessed using Morris water maze test.Aβ deposition and LRP1 expression in mice brain were investigated.Results.Pioglitazone treatment showed improvement in memory impairment.Pioglitazone-treated SAMP8 mice showed reduced Aβ deposition than vehicle-treated mice.In addition, increased LRP1 expression in microvessel was observed in pioglitazone-treated SAMP8 mice.Conclusion.These results suggest that pioglitazone may provide a protective effect against memory impairment through increasing LRP1 expression in blood-brain barrier and reducing Aβ deposition.Pioglitazone could have a therapeutic potential for the treatment of AD.- -----------------------
Author: 석한나
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2409208239