Year: 2015
Type: article
Abstract: The airway epithelium, which covers the luminal surface of the tracheobronchial tree, is a primary barrier that protects the lung from pathogens, irritants, toxic substances and other stressors present in the ∼10 000 L of air flowing through the airways every day. This barrier function is normally mediated by differentiated ciliated and secretory cells strategically positioned in the apical layer to interact with the luminal content. Via production of mucus and antimicrobial substances, and continuous beating of the cilia to remove mucus-trapped bacteria and other airborne particles from the airways, these cells protect the lung from respiratory damage and infection [1]. In addition, tight junctions (multiprotein complexes between the apical membrane domains of adjacent differentiated cells) control diffusion of the luminal content across the epithelium, preventing activation of numerous receptors and inflammatory cells enriched in the basolateral compartment or beneath the epithelium [2, 3]. Human airway basal stem cells contribute to host–microbe interactions and innate immunity in the lung <http://ow.ly/Q2UAF>
Source: European Respiratory Journal
Author: Renat Shaykhiev
Institution: Weill Cornell Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1467131289, G153856356, G1617283160, Integrative-omics Network Model of the Disordered COPD Small Airway Epithelium, Overlapping Airway Basal Cell Transcriptome Reprogramming in COPD and Lung Cancer, G4722577392, Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD, G8664531446
OpenAlex ID: W2409301626