Pharmacological activities of chlorpromazine involved in the inhibition of tumour necrosis factor production in vivo in mice.
Year: 1993
Type: article
Abstract: Chlorpromazine (CPZ) was shown to inhibit tumour necrosis factor (TNF) production in vivo. Several drugs sharing one of the various pharmacological activities of CPZ were tested in endotoxin-treated mice. It was found that alpha-blockers (prazosin, idazoxan, phenoxybenzamine), antiserotoninergics (methysergide, methergoline) and antihistamine (chlorpheniramine, promethazine) also inhibited TNF production indicating that the effectiveness of CPZ in protecting from endotoxin shock is due to its multiple pharmacological activities.
Source: PubMed Central
Authors: R Bertini, S Garattini, R Delgado, P Ghezzi
Institution: Mario Negri Institute for Pharmacological Research
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2409443511