Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.
Year: 1980
Type: article
Abstract: To test the hypothesis that complement-mediated cell lysis and cell-mediated cytotoxicity operate by analogous mechanisms, cell membranes from two antibody-dependent cytotoxicity systems were examined by electron microscopy after negative staining. Ring-shaped membrane lesions generally similar to, but larger than, those previously described for complement lysis were observed. These findings are in agreement with recent measurements of larger functional pores for ADCC than complement.
Source: PubMed
Authors: R R Dourmashkin, P Deteix, C B Simone, P Henkart
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2409458263