Work

Brief Report

Year: 2016

Type: article

Abstract: BACKGROUND: A previous study reported a negative association between perfluorooctane sulfonamide (PFOSA) concentrations and fecundability. METHODS: We examined this association among women enrolled in the Norwegian Mother and Child Cohort Study (MoBa), in 2003-2004. This analysis was restricted to 451 primiparous women to avoid bias due to previous pregnancy. Self-reported time-to-pregnancy (TTP) and plasma were obtained around 18 weeks of gestation. Approximately half of the women had measurable PFOSA levels; missing values were multiply imputed. We used the logistic analogue of discrete-time survival analysis to examine the adjusted association between PFOSA, other perfluoroalkyl substances, and TTP. RESULTS: The median-measured PFOSA concentration was 0.03 ng/ml (interquartile range = 0.02, 0.07). The age and body mass index-adjusted association between an interquartile distance increase in PFOSA and TTP was 0.91 (95% confidence interval = 0.71, 1.17). Imputation of missing PFOSA resulted in similar estimates. No association was observed with other perfluoroalkyl substances. CONCLUSION: Based on a weakly decreased fecundability odds ratio, we found only limited support for an association between plasma PFOSA concentrations and TTP among primiparous women. See Video Abstract at http://links.lww.com/EDE/B79.

Source: Epidemiology

DOI: 10.1097/ede.0000000000000524

Authors: Kristina W. Whitworth, Line S. Haug, Azemira Sabaredzovic, Merete Eggesbo, Matthew P. Longnecker

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences, Southwest Center for Occupational and Environmental Health, Norwegian Institute of Public Health

Language: English

Topic: Per- and polyfluoroalkyl substances research

Subfield: Environmental Chemistry

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Norwegian Institute of Public Health, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences