REFINEpro: A novel conformation ensemble approach to protein structure refinement
Year: 2015
Type: other
Abstract: Improving the overall fold of the initial models is one of the major challenges in protein structure refinement field. Here, we propose a novel conformation ensemble approach, called REFINEpro to tackle this problem. The protocol first identifies the less conserved local regions in the initial structure by consensus approach using ensemble of models produced for the same protein target. We call these regions problematic regions (PRs). Combined with our previous study on protein structure refinement, the qualities of the PRs are then iteratively improved by assembling better-modeled fragments corresponding to these PRs from structures in the ensemble. REFINEpro web service is freely available at: http://sysbio.rnet.missouri.edu/REFINEpro/ .
Authors: Debswapna Bhattacharya, Jianlin Cheng
Institution: University of Missouri
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W2409624821