Work

MTH1 counteracts oncogenic oxidative stress

Year: 2015

Type: article

Abstract: Oncogenic oxidative stress is an intrinsic part of the transformation process and needs to be mitigated for optimal malignancy in the transformed cancer cells. The source of oncogenic reactive oxygen species (ROS) likely differs depending on the stage of transformation and can be, separately or collectively, the result of hyperactivated oncogenic signaling, inflammation, aberrant mitochondrial metabolism, and instigation of invasion-promoting pathways[1]. In RAS-driven tumor cells, we have found that MTH1, the mammalian Nudix hydrolase that degrades oxidized purine nucleotides, effectively counteracts the resistance to transformation and malignancy from this inherent oxidative stress. Our work was the first to show that MTH1 is required to facilitate the formation, proliferation and tumorigenic capability of

Source: Oncoscience

DOI: 10.18632/oncoscience.240

Authors: Dominick G.A. Burton, Priyamvada Rai

Institution: University of Miami

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Cancer Institute