Acute respiratory distress syndrome following cardiovascular surgery
Year: 2015
Type: review
Abstract: PURPOSE OF REVIEW: This review gives an update on current treatment options and novel concepts on the prevention and treatment of the acute respiratory distress syndrome (ARDS) in cardiovascular surgery patients. RECENT FINDINGS: The only proven beneficial therapeutic options in ARDS are those that help to prevent further ventilator-induced lung injury, such as prone position, use of lung-protective ventilation strategies, and extracorporeal membrane oxygenation. In the future also new approaches like mesenchymal cell therapy, activation of hypoxia-elicited transcription factors or targeting of purinergic signaling may be successful outside the experimental setting. Owing to the so far limited treatment options, it is of great importance to determine patients at risk for developing ARDS already perioperatively. In this context, serum biomarkers and lung injury prediction scores could be useful. SUMMARY: Preventing ARDS as a severe complication in the cardiovascular surgery setting may help to reduce morbidity and mortality. As cardiovascular surgery patients are of greater risk to develop ARDS, preventive interventions should be implemented early on. Especially, use of low tidal volumes, avoiding of fluid overload and restrictive blood transfusion regimes may help to prevent ARDS.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Amphiregulin Signaling in Perioperative Cardio-Protection, Hypoxia Inducible Factor in Acute Lung Injury, Hypoxic Adenosine Responses, Extracellular Adenosine During Ventilator Induced Lung Injury, Proton Pump Inhibitors for Perioperative Acute Kidney Injury, Alternative Mechanisms of Adenosine Receptor Activation, G864227254
OpenAlex ID: W2410253759