5-hydroxytryptophan Decarboxylase: Preparation and Properties
Year: 1954
Type: article
Abstract: Although 5-hydroxytryptamine was only recently discovered (l), the evidence already at hand indicates that it is present in practically all animal species (24) and that it possesses unusual pharmacological properties (5, 6). It may well rank with epinephrine, norepinephrine, and histamine as one of the important regulatory amines of the body. Studies carried on in this laboratory on the biosynthesis of 5-hydroxytryptamine in animals indicate that tryptophan is the precursor, being converted by oxidation to 5-hydroxytryptophan, which then undergoes decarboxylation to yield 5hydroxytryptamine (7). The studies reported in this paper concern the enzyme, 5-hydroxytryptophan decarboxylase. Procedures for purification of the enzyme obtained from hog and guinea pig kidney homogenates and acetone-dried powders and some properties of these preparations are described.
Source: Journal of Biological Chemistry
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2410356622