Work

A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells

Year: 2016

Type: article

Abstract: In contrast to fibroblasts, epithelial cells spontaneously escape from senescence and develop clones of mutated, transformed, and tumorigenic cells. Recently, we revealed that accumulation of unrepaired DNA single-strand breaks is a trigger of the p16 (CDKN2)-dependent cell cycle arrest pathway in senescent epithelial cells and also the mutagenic motor of post-senescence neoplastic escape.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2016.1190885

Authors: Joe Nassour, Corinne Abbadie

Institutions: Salk Institute for Biological Studies, Centre National de la Recherche Scientifique, Université de Lille, Institut Pasteur de Lille

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze