Dynamics of cell polarity in tissue morphogenesis: a comparative view from Drosophila and Ciona
Year: 2016
Type: review
Abstract: Tissues in developing embryos exhibit complex and dynamic rearrangements that shape forming organs, limbs, and body axes. Directed migration, mediolateral intercalation, lumen formation, and other rearrangements influence the topology and topography of developing tissues. These collective cell behaviors are distinct phenomena but all involve the fine-grained control of cell polarity. Here we review recent findings in the dynamics of polarized cell behavior in both the Drosophila ovarian border cells and the Ciona notochord. These studies reveal the remarkable reorganization of cell polarity during organ formation and underscore conserved mechanisms of developmental cell polarity including the Par/atypical protein kinase C (aPKC) and planar cell polarity pathways. These two very different model systems demonstrate important commonalities but also key differences in how cell polarity is controlled in tissue morphogenesis. Together, these systems raise important, broader questions on how the developmental control of cell polarity contributes to morphogenesis of diverse tissues across the metazoa.
Source: F1000Research
Authors: Michael T. Veeman, Jocelyn A. McDonald
Institution: Kansas State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,350
Awards: Phosphatase Control of Collective Cell Migration during Development, Consequence of collective cell invasion in glioblastoma, G2921881625, G6020269795, Molecular Analysis of Disease Pathways, Morphogenetic effector networks in the Ciona notochord, Linking Cell Shape and Asymmetric Division in Ciona Notochord Tapering, Kansas IDeA Network of Biomedical Research Excellence 5
OpenAlex ID: W2410953156