Case report congenital LQTS--an electrocardiographic and genotype correlation.
Year: 2005
Type: article
Study design: Case Report
Abstract: The congenital Long QT Syndrome (LQTS) is characterized by abnormally prolonged ventricular repolarization due to inherited defect in cardiac sodium and potassium channels, which predisposes the patients to syncope, ventricular arrhythmias, and sudden cardiac death. Early diagnosis and preventive treatment are instrumental to prevent sudden cardiac death in patients with the congenital LQTS. The diagnostic criteria for congenital LQTS are based on certain electrocardiographic findings and clinical history. Recently genotype specific electrocardiographic pattern in the congenital LQTS has also been described. Recent studies suggest feasibility of genotype specific treatment of LQTS and in near future, mutation specific treatment will probably become a novel approach to this potentially fatal syndrome. We describe two cases that fulfilled the electrocardiographic and historical diagnostic criteria with morphology on electrocardiogram (ECG) suggestive of LQT1 genotype.
Source: PubMed
Authors: Naveed Akhtar, Waqas Ahmed, Mehnaz Mehboob
Institution: Shifa International Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2411506151