Work

The Effect of Different Bypass Flow Rates and Low-Dose Dopamine on Gut Mucosal Perfusion and Outcome in Cardiac Surgical Patients

Year: 1999

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: The aim of this double-blind, randomized, placebo-controlled trial was to investigate the effects of different cardiopulmonary bypass flow rates and low-dose dopamine on gastric mucosal pH (pHi) and outcome. We hypothesized that by minimizing gut mucosal hypoperfusion during and after cardiac surgery endotoxin translocation may be prevented, resulting in an improved clinical outcome. Four groups of 25 patients each receiving high or low flows during bypass and low-dose dopamine or saline for 24 hours after induction of anaesthesia were studied. The pHi was measured at six time intervals over 24 hours. The combination of low-dose dopamine and a low bypass flow rate was associated with a significantly greater frequency and severity of low pHi. This group also demonstrated a significantly lower vascular resistance on admission to the intensive care unit. There may be an association between low pHi and low vascular resistance.

Source: Anaesthesia and Intensive Care

DOI: 10.1177/0310057x9902700103

Authors: M. Schneider, S. Valentine, R. M. Hegde, J. Peacock, S. March, G. J. Dobb

Institution: Royal Perth Hospital

Language: English

Topic: Cardiac and Coronary Surgery Techniques

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Australian and New Zealand College of Anaesthetists, Australian Society of Anaesthetists