Work

p53 Arg72Pro polymorphism and risk of basal cell carcinoma: a meta analysis.

Year: 2015

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: PURPOSE: We attempted to comprehensively assess the possible association between p53 Arg72Pro polymorphism and the risk of basal cell carcinoma (BCC). METHODS: We performed a literature search of case-control association studies on p53 Arg72Pro polymorphism and BCC susceptibility in PubMed and EMBASE. 7 eligible studies were finally identified and their data were extracted for this meta-analysis. BCC risk was determined with the fixed effects model using a pooled odds ratio (OR). RESULTS: Using distinct genetic models, we found that p53 Arg72Pro polymorphism was not associated with the overall risk of BCC. We observed a similar trend towards the association when performing subgroup analysis for Caucasians and Asians. CONCLUSION: Our results suggest that presence of the common p53 Arg72Pro polymorphism may not play a role in the development of BCC. Larger studies are needed to better confirm the association.

Source: PubMed Central

Authors: Yanli Tian, Li Li, Rongya Yang

Institutions: Chinese PLA General Hospital, Chinese People's Liberation Army, The Military General Hospital of Beijing PLA

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2412077271

FWCI: 0.349

Cites: 33

Cited by: 1

Related to: 10