Work

Roles of antibody against oxygenized low density lipoprotein in atherosclerosis: recent advances.

Year: 2015

Type: article

Abstract: Atherosclerosis is a chronic immune inflammatory disease. Atherosclerosis and relevant disease are threatening human life and health. Oxygenized low density lipoprotein (oxLDL) is a molecular basis in the pathogenesis of atherosclerosis and able to induce inflammation, stimulate immune system and interfere with lipid metabolism in the occurrence and development of atherosclerosis. Antibody against oxLDL has been an important molecule in the immune related pathogenesis of atherosclerosis. In available studies on atherosclerosis, antibody against oxLDL has been a focus, but how oxLDL acts to affect the atherosclerosis and relevant diseases, whether oxLDL is protective or detrimental, and whether oxLDL acts in different ways at different stages of atherosclerosis are still unclear. This paper focuses on the role of antibody against oxLDL in the atherosclerosis and relevant diseases, and summarizes the advances in this field, aiming to provide new clue and new methods for the therapy of atherosclerosis.

Source: Europe PMC (PubMed Central)

Authors: Jing Zhang, Daxin Wang, Shenghu He

Institutions: Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University, Northern Jiangsu People's Hospital, Yangzhou University

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2412181109

FWCI: 1.163

Cites: 47

Cited by: 20

Related to: 10