Work

Mechanism and Function of Angiogenin in Hematopoietic Malignancy.

Year: 2015

Type: article

Abstract: Angiogenic factors have been widely implicated in the formation and progression of solid tumors. A number of angiogenic mediators have been recently appreciated as having equivalent function in non-solid tumors, such as leukemia. One such factor, angiogenin (ANG), promotes tumor cell growth and angiogenesis in solid cancers; however its precise function(s) in hematological disorders are not fully understood. This review summarizes current knowledge of the function and therapeutic potential of angiogenic factors, with particular emphasis on the role and hypothesized mechanism of ANG in a non-solid tumor setting.

Source: PubMed

Authors: Kevin A Goncalves, Guo-Fu Hu

Institution: Tufts Medical Center

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke

Awards: Mechanism of angiogenin-induced angiogenesis, Angiogenin in ALS Pathobiology and Therapy, Role of Angiogenin in Hematopoietic Stem Cell Quiescence and Self-renewal