Year: 2006
Type: article
Study design: Observational Study
Abstract: To localize quantitative trait loci for insulin metabolism and obesity, genome scans/linkage analyses were performed on >900 members of 32 extended families participating in phase 3 of the Strong Heart Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota. Linkage analyses of fasting insulin and two obesity-related phenotypes, BMI and percent fat mass, were performed independently in each of the three populations. For log fasting insulin, we found a genome-wide maximum, robust logarithm of odds (LOD) score of 3.42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas.
Source: Diabetes
DOI: 10.2337/db05-0668
Authors: Vincent P. Diego, Harald H.H. Göring, Shelley A. Cole, Laura Almasy, Thomas D. Dyer, John Blangero, Ravindranath Duggirala, Sandra Laston, Charlotte Wenger, Teresa Cantu, Bennett Dyke, Kari North, Theodore Schurr, Lyle G. Best, Richard B. Devereux, Richard R. Fabsitz, Barbara V. Howard, Jean W. MacCluer
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2413022615