Work

Neural stem/progenitor cells in Alzheimer's disease.

Year: 2016

Type: article

Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to reverse or slow the loss of affected neurons. Another plausible therapeutic way that may complement the studies is to increase the survival of existing neurons by mobilizing the existing neural stem/progenitor cells (NSPCs) - i.e. "induce their plasticity" - to regenerate lost neurons despite the existing pathology and unfavorable environment. However, there is controversy about how NSPCs are affected by the unfavorable toxic environment during AD. In this review, we will discuss the use of stem cells in neurodegenerative diseases and in particular how NSPCs affect the AD pathology and how neurodegeneration affects NSPCs. In the end of this review, we will discuss how zebrafish as a useful model organism with extensive regenerative ability in the brain might help to address the molecular programs needed for NSPCs to respond to neurodegeneration by enhanced neurogenesis.

Source: Europe PMC (PubMed Central)

Authors: Gizem Tincer, Violeta Mashkaryan, Prabesh Bhattarai, Caghan Kizil

Institutions: Center for Regenerative Therapies Dresden, German Center for Neurodegenerative Diseases (DZNE) Dresden, Technische Universität Dresden

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2413109756

FWCI: 3.409

Cites: 188

Cited by: 54

Related to: 10