Year: 2016
Type: article
Abstract: : CD30 is a member of the tumor necrosis factor receptor family and is expressed on activated lymphocytes and a few other normal cells. Its signaling activates NF-κB transcription factor, resulting in pleiotropic regulation of gene function. CD30 is the characteristic marker of classical Hodgkin lymphoma, anaplastic large-cell lymphoma, and embryonal cell carcinoma, and it is expressed on a subset of aggressive T- and B-cell neoplasms. Its restricted expression on normal cells makes it an attractive candidate for targeted therapy. The underlying molecular alterations in these malignancies serve to explain the need for a toxin-bound therapeutic reagent. Keywords : NF-κB, Hodgkin lymphoma, TNF-R, ALCL
DOI: 10.2147/plmi.s89466
Author: Susan RS Gottesman
Institution: SUNY Downstate Health Sciences University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,806
OpenAlex ID: W2413700372