Work

Telomeres, cancer & aging: live long & prosper?

Year: 2013

Type: article

Abstract: Like our clothes, our chromosomes fray at the edges with age. Some believe that if we could discover a molecular tailor to patch our age-abraded chromosome ends, we could become modern Methuselahs. Notably, cancer cells achieve immortality by protecting their chromosome ends. Drugs that selectively fray the ends of cancer cell chromosomes would be potent and general anti-cancer therapies. Here, I summarize data on the role of chromosome ends in cellular and organismal aging.

Source: Europe PMC (PubMed Central)

Author: Joel C Eissenberg

Institution: Saint Louis University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2413783736

FWCI: 0.548

Cites: 15

Cited by: 7

Related to: 10