Wpływ leczenia simwastatyną i prawastatyną na wartości pomiarów ambulatoryjnych oraz rytm dobowy ciśnienia tętniczego krwi u pacjentów z nadciśnieniem tętniczym pierwotnym i hiperlipidemią - badanie pilotażowe, randomizowane
Year: 2001
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Wpływ leczenia simwastatyną i prawastatyną na wartości pomiarów ambulatoryjnych oraz rytm dobowy ciśnienia tętniczego krwi u pacjentów z nadciśnieniem tętniczym pierwotnym i hiperlipidemią -badanie pilotażowe, randomizowane The Effects of Simvastatin and Pravastatin on Office Blood Pressure and 24-hour Blood Pressure Pattern in Patients with Essential Hypertensin and Hypercholesterolemia -Pilot, Randomised Study SummaryBackground We studied the effect of statin therapy (simvastatin or pravastatin) on office blood pressure and 24-hour blood pressure pattern in patients with essential arterial hypertension and hypercholesterolemia, taking antihypertensive drugs. Material and methodsThe study was in 23 patients (pts), women: 13, men: 10, age 50-72 (mean 60,2), with chronic arterial hypertension.Treatment: indapamid 1,5 mg a day, enalapril 20-40 mg a day.Patients with basal total cholesterol (TC) 6,5-10,0 mmol/l, LDL cholesterol (LDL-C) > > 4,1 mmol/l and triglyceride (TG) < 3,5 mmol/l were included.After 6 week run-in period and hypolipemic diet therapy patients were divided in two groups: the I group-included 11 pts treated with simvastatin 10--20 mg a day for 12 weeks.In the II group -12 pts were given pravastatin 10-20 mg a day for 3 months.Blood pressure was measured with the traditional method (standardised mercurial manometers) every 6 weeks.After 6 weeks of treatment because of a higher cholesterol values, the dose increase was required (from 10 mg to 20 mg) in 2 patients of 11 treated with simvastatin and 3 of 12 trated with pravastatin.After the placebo period, and after 6 and 12 weeks of treatment with statins 24-hour ambulatory blood pressure measurements (ABPM) were performed with Spacelab 90207 recorder. ResultsIn both 6-week and 12-week simvastatin treatment periods, statistically significant reduction of systolic blood pressure (SBP) measured by standard method, as compared to the placebo period was observed {135 ± 3,2 mm Hg Æ Æ 121,1 ± 13,1 mm Hg (p < 0,05) Æ 116,2 ± 1,4 mm Hg (p < 0,01) on placebo and after 6 and 12 weeks of simvastatin, respectively}.In the same group of patients and period given diastolic blood pressure values tended to decrease 83 ± 2,2 Æ 80,5 ± 2,8 mm Hg.After 3 months to follow-up in ABPM we observed only a tendency to decrease values of blood pressure.We observed a greater reduction of SBP and DBP values during the day than during the night.In pravastatin group the BP was not lowered significantly. ConclusionThe result of this study demonstrate that the use of simvastatin in combination with antihypertensive drugs, unlike pravastatin, can reduce the level of SBP providing adequate control of hypertension and cholesterol levels.
Source: Via Medica Journals
Authors: Praca Oryginalna, Joanna Niegowska, Marko Boh
Language: Polish
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2413918643