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Evidence that poly(ADP-ribose) polymerase is involved in the loss of NAD from cultured rat liver cells

Year: 1982

Type: article

Abstract: Rat hepatocytes cultured from 24h lose 60% of their NAD content. By using the differential response to inhibitors of the two major enzymes that catabolize NAD in mammalian cells, it is shown that poly(ADP-ribose) polymerase is responsible for the loss of NAD. The relevance of this observation to the use of cultured hepatocytes for the study of DNA repair induced by carcinogens is discussed.

Source: Biochemical Journal

DOI: 10.1042/bj2020551

Authors: A J Paine, C M Allen, B W Durkacz, S Shall

Institutions: University of Sussex, MRC Toxicology Unit, Medical Research Council

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2413935100

FWCI: 1.02

Cites: 11

Cited by: 12

Related to: 10