Work

Association of genetic polymorphisms in HTR3A and HTR3E with diarrhea predominant irritable bowel syndrome.

Year: 2015

Type: article

Abstract: OBJECTIVE: The present study aims to investigate the relationship between genetic polymorphisms in HTR3A and HTR3E and diarrhea predominant irritable bowel syndrome (D-IBS) in a Chinese population. METHODS: We enrolled 500 D-IBS patients and 500 age- and sex-matched healthy control subjects to detect the genotypes in HTR3A and HTR3B gene by using of PCR-RFLP method. RESULTS: There were significant difference between the D-IBS patients and the health control subjects in the distribution of genotype and allele of rs1062613 in HTR3A gene. As regarding rs62625044 in HTR3E gene, we found there was a significant different between the case and the control group in the distribution of GA genotype and A allele in female but not in male. CONCLUSION: The present study suggested that there are associations of D-IBS risk with genetic polymorphisms in HTR3A and HTR3E.

Source: Europe PMC (PubMed Central)

Authors: Qiao-Yan Gu, Jun Zhang, Yi-Chao Feng, Guang-Rong Dai, Wei-Ping Du

Institutions: Yan'an University, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Yanan University Affiliated Hospital

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2414179833

FWCI: 2.204

Cites: 21

Cited by: 18

Related to: 10