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Reversible Fluoxetine-Induced Hyperthyroidism

Year: 2015

Type: article

Abstract: BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare. CASE: We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after discontinuation of fluoxetine and administration with venlafaxine. In the first year of follow-up, her thyroid functions as well as her depressive symptoms remained perfectly normal. CONCLUSIONS: This case highlights the necessity of monitoring thyroid profiles during SSRI treatment.

Source: Clinical Neuropharmacology

DOI: 10.1097/wnf.0000000000000116

Authors: Jianbo Lai, Dongrong Xu, Bradley S. Peterson, Yi Xu, Ning Wei, Minming Zhang, Shaohua Hu

Institutions: University of Southern California, First Affiliated Hospital Zhejiang University, New York State Psychiatric Institute, Zhejiang University, Columbia University, Children's Hospital Los Angeles, Second Affiliated Hospital of Zhejiang University

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2414790227

FWCI: 0.261

Cites: 13

Cited by: 7

Related to: 10