Work

Methods for assessing cell-mediated immunity in infectious disease resistance and in the development of vaccines

Year: 1995

Type: article

Abstract: Immunologic evaluation of vaccines has depended largely on the measurement of an antibody response in the serum of recipient animals. This approach, which worked well for diseases prevented in large part by humoral immunity, ignored the contributions cell-mediated immunity (CMI) or mucosal immunity make to providing protection against many infectious diseases. As a result of this approach, certain vaccines were marketed that produced a satisfactory antibody response but failed to protect vaccinates in the field from disease. In the modem biologics industry, there is increasing pressure for vaccine improvements and new technologic advancements to be based on a sound understanding of the entire basis for immunity, including cell-mediated, mucosal, and humoral immunity that develops after exposure to infectious disease agents.

Source: Journal of the American Veterinary Medical Association

DOI: 10.2460/javma.1995.206.08.1208

Authors: Nancy E. Coe Clough, James A. Roth

Institutions: Animal and Plant Health Inspection Service, United States Department of Agriculture, Iowa State University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2415122666