Novel Peptide-Specific Quantitative Structure–Activity Relationship (QSAR) Analysis Applied to Collagen IV Peptides with Antiangiogenic Activity
Year: 2011
Type: article
Abstract: Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm200114f
Institutions: Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: green
Awards: Networks, Pathways and Dynamics of Lysine Modification, Networks, Pathways and Dynamics of Lysine Modification, Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancer, Systems Biology of Angiogenesis in Peripheral Arterial Disease, Nanoparticle-mediated peptide delivery for breast cancer
OpenAlex ID: W2415324896