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Itch promotes the neddylation of JunB and regulates JunB-dependent transcription

Year: 2016
Type: article
Abstract: Protein neddylation is essential for the viability of most organisms and is widely involved in the regulation of immunity, DNA damage and repair, cell signaling and cell cycle. Unlike RING-type neddylation ligases, HECT-type neddylation ligase remains less defined. Here, we show that Itch is a novel HECT-type neddylation E3 ligase and we identify JunB as a substrate of Nedd8 modification by Itch. JunB neddylation attenuates its transcriptional activity. In addition, JunB neddylation mediated by Itch promotes its ubiquitination-dependent degradation. Therefore, these findings define a new HECT-type neddylation ligase and its neddylation substrate.
DOI: 10.1016/j.cellsig.2016.05.016
Authors: Haiwen Li, Heng Zhu, Yang Liu, Fuchu He, Ping Xie, Lingqiang Zhang
Institutions: Beijing Proteome Research Center, State Key Laboratory of Proteomics, Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, Guiyang College of Traditional Chinese Medicine, Capital Medical University, Dalian Medical University
Language: English
Open Access status: hybrid
Estimated APC paid: $3,550
OpenAlex ID: W2415416474
FWCI: 1.56
Cites: 45
Cited by: 33
Related to: 10