Work

Complement Component C3 Mediates Th1/Th17 Polarization in Human T Cell Activation and Cutaneous Graft-Versus-Host Disease

Year: 2014

Type: article

Abstract: Graft-verses-host disease (GVHD) is a major complication in allogeneic bone marrow transplantation (allo-HSCT), and characterized by epithelial cell injury in skin, intestine and liver. The development of GVHD involves donor T cell activation including proliferation, differentiation and inflammatory cytokine production, which lead to specific tissue damage. The interactions between the complement system and lymphocytes have been shown to regulate alloreactive T cell and APC function in the setting of allograft rejection.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.460

Authors: Qing Ma, Dan Li, Amin M. Alousi, Richard E. Champlin, George E. Sale, Vahid Afshar-Kharghan

Institutions: The University of Texas MD Anderson Cancer Center, University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650