Work

Inhibition of protein-protein interactions with low molecular weight compounds.

Year: 2008

Type: article

Abstract: An overview of issues associated with the design and development of low molecular weight inhibitors of protein-protein interactions is presented. Areas discussed include information on the nature of protein-protein interfaces, methods to characterize those interfaces and methods by which that information is applied towards ligand identification and design. Specific examples of the strategy for the identification of inhibitors of protein-protein interactions involving the proteins p56lck kinase, ERK2 and the calcium-binding protein S100B are presented. Physical characterization of the inhibitors identified in those studies shows them to have drug-like and lead-like properties, indicating their potential to be developed into therapeutic agents.

Source: PubMed

Authors: Marilyn M Matthews, David J Weber, Paul S Shapiro, Andrew Coop, Alexander D Mackerell

Institution: University of Maryland, Baltimore

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: Substrate specific ERK docking domain inhibitors, Restoration of Tumor Suppression Activity in Malignant Melanoma

OpenAlex ID: W2416936398

FWCI:

Cites: 117

Cited by: 4

Related to: 10