Year: 2016
Type: article
Study design: Observational Study
Abstract: Nucleotide Excision Repair (NER) is a critical pathway involved in breast cancer (BC). We have previously published that a low DNA repair capacity (DRC) is associated with a higher risk of BC in Puerto Rican women. Let-7b belongs to a miRNA family with tumor suppressor activity that targets oncogenes. We isolated miRNAs from plasma of 153 Puerto Rican women with and without BC. DRC was measured in lymphocytes by means of a host cell reactivation assay. These women were divided into four groups according to their DRC level: High (>3.8%) and low (<3.8%). The four groups consisted of BC patients with high (n = 35) and low (n = 43) DRC and controls with high (n = 39) and low (n = 36) DRC. Epidemiologic data were collected at initial BC diagnosis and almost five years after diagnosis. A significant difference in Let-7b expression was found in BC patients with high DRC versus the remaining groups (p < 0.001). Thus, our data reveal a possible role of Let-7b on DRC during breast carcinogenesis. Our study is innovative because it provides the first evidence that Let-7b may play role in DRC regulation (through the NER repair pathway) in BC.
DOI: 10.3390/ijms17060865
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G3648021098, FUNCTIONAL ANALYSIS OF BRCA1 MUTANTS, G375134335, G415120227, University of Puerto Rico Ponce Research Initiative for Enhancement: UPR-PRISE, G5169588405, RCMI Program at Ponce School of Medicine: Addressing Health Disparities, Factors associated with variability in DNA repair capacity in their effect on bre, G7272977376, G7436738697, Ponce_Health_Sciences_University_RISE_Graduate_Training_Program., G867620348, MBRS SCORE Program at the Ponce School of Medicine, G9000139123, 2/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership, (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership #
OpenAlex ID: W2417046094