Progress in the Discovery and Development of Heat Shock Protein 90 (Hsp90) Inhibitors
Year: 2014
Type: article
Abstract: The discovery and clinical development of heat shock protein 90 (Hsp90) inhibitors continue to progress. A number of Hsp90 inhibitors are in clinical trials, and preclinical discoveries of new chemotypes that bind to distinct regions in the protein as well as isoform selective compounds are active areas of research. This review will highlight progress in the field since 2010.
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm500823a
Institution: Montclair State University
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2417397441