Year: 1986
Type: article
Abstract: This paper extends our studies of the local and distant suppressions of skin-test responses to mixed mycobacterial reagents previously demonstrated in Nepal and Bombay.Several new mixtures were prepared, which included DEAE separated fractions of a sonicate of My cobacterium vaccae (Vaccin).Local suppression was a major fe ature of the results in ali the centres except Kopri in Bombay.Ali of the Vaccin fractions were capable of inducing local suppression.Distant suppression associated with ali the fr actions was observed at one of the Bombay centres, but not the other (p < O•OOOO I).In Kenya distant suppression also occurred at only one of the centres (p < 0'00003), but at this centre it was associated significantly with only 2 of the 5 fractions tested (p < 0•00 I in each case).Our results may well depend on geographical differences probably associated with the quantity and quality of sensitization by fa st-growing environmental mycobacteria.The possibly essential part played by suppressor determinants within the fractions described in the initial infection with M. leprae and in the pathogenesis of multibacillary disease is discussed.
Source: Leprosy Review
Authors: P. M. NYE, J. L. STANFORD, G. A. W. ROOK, P. LAWTON, M. MACGREGOR, C. REILY, D. HUMBER, P. OREGE, C. R. REVANKAR, J. TERENCIO DE LAS AGUAS, P. TORRES
Institution: Armauer Hansen Research Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2417447459