Work

Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo.

Year: 2004

Type: article

Abstract: Visceral leishmaniasis (VL), also known as kala-azar, is a vector-borne disease caused by protozoa of the Leishmania donovani complex. It is usually fatal if untreated. Pentavalent antimonials have been the mainstay of treatment for more than 60 years, but these drugs have serious side effects and progressive antimonial resistance.1 Other proven therapeutics such as amphotericin B, pentamidine, and paromomycin are costly without oral formulation and unpleasant side effects.2 Thus, new chemotherapeutic drugs are required to supplement or replace currently available drugs.

Source: PubMed

Authors: Ying Ma, Dian-mei Lu, Xiao-jun Lu, Lin Liao, Xiao-su Hu

Institution: Sichuan University

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W242077066

FWCI: 0.365

Cites:

Cited by: 26

Related to: 10