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Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.

Year: 1988

Type: article

Abstract: Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts. NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the majority of the target cells infected with most of the low passage strains. The magnitude of NK lysis of different CMV-infected target cells did not correlate with their ability to induce IFN-alpha. NK cell-mediated lysis of cells infected with low-passage clinical isolates of CMV required both NK cells and HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.

Source: PubMed

Authors: S Bandyopadhyay, S H Oh, S Michelson, D S Miller, J L Virelizier, S E Starr

Institution: Children's Hospital of Philadelphia

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2418201843

FWCI: 0.292

Cites: 22

Cited by: 8

Related to: 10