Work

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

Year: 2016

Type: review

Abstract: Loss of cellular homeostasis during aging results in altered tissue functions and leads to a general decline in fitness and, ultimately, death. As animals age, the control of gene expression, which is orchestrated by multiple epigenetic factors, degenerates. In parallel, metabolic activity and mitochondrial protein acetylation levels also change. These two hallmarks of aging are effectively linked through the accumulating evidence that histone acetylation patterns are susceptible to alterations in key metabolites such as acetyl-CoA and NAD(+), allowing chromatin to function as a sensor of cellular metabolism. In this review we discuss experimental data supporting these connections and provide a context for the possible medical and physiological relevance.

Source: Trends in Biochemical Sciences

DOI: 10.1016/j.tibs.2016.05.008

Authors: Shahaf Peleg, Christian Feller, Andreas G. Ladurner, Axel Imhof

Institutions: Ludwig-Maximilians-Universität München, ETH Zurich, Institute for Molecular Systems Biology, Center for Integrated Protein Science Munich, Munich Cluster for Systems Neurology

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030